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Past Projects by Health Concern

Selected Papers by Health Concern

In 25 years of research, our Center has studied the effects of integrative therapies on a variety of diseases/disorders.  Below is a list of selected publications that describe our findings:



  1. Zhang R, Lao L, Ren K, Berman BM.  Mechanisms of Acupuncture-Electroacupuncture on Persistent Pain.  Anesthesiology. 2013 Dec 9. [Epub ahead of print]  PMID: 24322588. PMCID: PMC3947586.

  2. Zhang R, Li A, Liu B, Wang L, Ren K, Zhang H, Berman B, Lao L.  IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats. Pain.  2008 Apr;135(3):232-9.  PMID: 17689191. PMCID: PMC2323207.

  3. Kundu A, Berman B.  Acupuncture for Pediatric Pain and Symptom Management.  Pediatr Clin N Am.  2007.  54; 885–899. 

  4. Astin J.  Mind-Body Therapies for the Management of Pain.  Clinical Journal of Pain 2004; 20 (1):27-32.

  5. Berman B. Integrative approaches to pain management: How to get the best of both worlds. British Medical Journal 2003; 326(7402):1320-1321.   PMCID: PMC1126192.

  6. Ezzo JE, Berman B, Hadhazy VA, Jadad AR, Lao L, Singh. Is acupuncture effective for the treatment of chronic pain? A systematic review. PAIN 2000; 86(3):217-225.

  7. Berman B, Bausell RB. The use of non-pharmacological therapies by pain specialist.  PAIN 2000; 85(3)313-315.

Back Pain

  1. Zhang Y, Meng X, Li A, Xin J, Berman BM, Lao L, Tan M, Ren K, Zhang RX. Electroacupuncture alleviates affective pain in an inflammatory pain rat model. Eur J Pain. 2011 Aug 3. [Epub ahead of print]  PMID: 22323370. PMCID: PMC3266461.

  2. Berman BM, Langevin HM, Witt CM, Dubner R.  Acupuncture for Chronic Low Back Pain.  N Engl J Med. 2010 Jul 29;363(5):454-461.  PMID: 20818865.

  3. Ee C, Manheimer E, Pirotta M, White A.  Acupuncture for pelvic and back pain in pregnancy: a systematic review.  American Journal of Obstetrics & Gynecology.  2008 March: 198(3):254-9. PMID: 18313444.
  4. Furlan AD, Tulder M, Cherkin D, Tsukayama H, Lao L, Koes B, Berman B. Acupuncture and dry-needling for low back pain: an updated systematic review within the framework of the Cochrane Collaboration. Spine. 2005; 30(8):944-63.

  5. Manheimer E, White A, Berman B, Forys K, Ernst E. Meta analysis: Acupuncture for low back pain. Annals of Internal Medicine. 2005; 142(8):651-663.

  6. Furlan A, Tulder M, Cherkin D, Tsukayama H, Lao L, Koes B, Berman B. Acupuncture and dry-needling for low back pain. Cochrane Database Systematic Reviews 2005; (1):CD001351.

Knee Pain

  1. Berman, B. A 60-Year-Old Woman Considering Acupuncture for Knee Pain.  JAMA; Clinical Crossroads. 2007; 297(15):1697-1707.


  1. Chen KW, Hou F, Litchbroun AS. Two Cases of Complete Recovery from Fibromyalgia Syndrome after External Qigong Therapy.  Alternative & Integrative Medicine. 21 Sept 2014; 3:4.

  2. Chen, K.,  Hassett, AL., Hou, F., Staller, J., Litchbroun, AS.  A pilot study of external qigong therapy for patients with Fibromyalgia.  The Journal of Alternative & Complementary Medicine. 2006: 12(9): 851-856.

  3. Astin J, Berman B, Bausell B, Lee W, Hochberg M, Forys K. The efficacy of mindfulness meditation plus Qigong movement therapy in the treatment of fibromyalgia:  A randomized controlled trial. Journal of Rheumatology 2003; 30(10):2257-2262.

  4. Hadhazy VA, Ezzo J, Creamer P, Berman B. Mind-body therapies for the treatment of fibromyalgia.  A systematic review.  Journal of Rheumatology 2000; 27(12):2911-2818.


  1. Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR.  Acupuncture for tension-type headache.  Cochrane Database Syst Rev. 2009 Jan 21;(1) PMID: 19160338. PMCID: PMC3099266.

  2. Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR.  Acupuncture for migraine prophylaxis.  Cochrane Database Syst Rev. 2009 Jan 21;(1) PMID: 19160193. PMCID: PMC3099267.


General Inflammation

  1. D'Adamo CR, Miller RR, Shardell MD, Orwig DL, Hochberg MC, Ferrucci L, Semba RD, Yu-Yahiro JA, Magaziner J, Hicks GE.  Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture.  Clin Nutr. 2012 Oct;31(5):659-65. doi: 10.1016/j.clnu.2012.01.013. Epub 2012 Feb 25.  PMID: 22365613. PMCID: PMC3412071.

  2. Yang Z, Grinchuk V, Ip SP,  Che CT, Fong HHS, Lao L, Wu J, Sung JJ, Berman B, Shea-Donohue T, Zhao A.  Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine.  Vol. 2012, Article ID 491496. doi:10.1155/2012/491496. PMID: 22461841. PMCID: PMC329646.

  3. Yang YH, Rajaiah R, Lee DY, Ma Z, Yu H, Fong HH, Lao L, Berman BM, Moudgil KD. Suppression of ongoing experimental arthritis by a Chinese herbal formula (huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation. Evid Based Complement Alternat Med. 2011;2011:642027. Epub 2010 Oct 19.  PMID: 20981317 [PubMed - in process] PMCID: PMC2958519.

  4. Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee D, Berman B, Moudgil K, Fong H, van Breemen R.  Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.  Pharmacological Research.  2010 Jun;61(6):519-24. Epub 2010 Feb 24.  PMID: 20188172. PMCID: PMC2860736.

  5. Rajaiah R, Lee DY, Ma Z, Fan AY, Lao L, Fong HH, Berman BM, Moudgil KD.  Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation. Journal of Ethnopharmacology 2009 May 4;123(1):40-4. Epub 2009 Mar 4.  PMID: 19429337. PMCID: PMC2925191.

  6. Li A., Lao L., Wang Y., Xin J., Ren K., Berman B., Tan, M., Zhang, R.  Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalamus to alleviate edema in a rat model of inflammation.  BMC Complementary and Alternative Medicine 2008 May; 8:20. PMID:18474100. PMCID: PMC2408560.

  7. Li, A., Zhang, RX., Wang, Y., Zhang, H., Ren, K., Berman, BM., Tan, M., Lao, L.  Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation.  BMC Complementary and Alternative Medicine 2007, 7:27.  PMCID: PMC1976320.

  8. Lao, L., Fan, A.Y., Zhang, R-X, Zhou, A.N., Ma, Z-Z, Lee D.Y-W, Ren, K., Berman, B.,  Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in Rats.  American Journal of Chinese Medicine 34; 5, 2006:  833-844. 

  9. Zhang RX, Wang L, Wang X, Ren K, Berman B, Lao L. Electroacupuncture combined with mk-801 prolongs anti-hyperalgesia in rats with peripheral inflammation. Pharmacology, Biochemistry and Behavior 2005; 81(1):146-151.

  10. Zhang RX, Lao L, Qiao JT, Malsnee K, Ruda MA. Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation. Neuroscience Letters 2004; 359(1-2):85-88.

  11. Zhang RX, Lao L, Qiao JT, Ruda MA. Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation. Brain Research 2004; 999(1):135-141.

  12. Zhang RX, Lao L, Qiao JT, Ruda MA. Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation. Neuroscience Letters 2003; 353(3):213-216.

  13. Berman B, Swyers JP, Ezzo J. The evidence for acupuncture as a treatment for rheumatologic conditions. Rheumatic Diseases Clinics of North America. 2000; 26(1):103-115, ix-x. Review.


  1. Lao L, Hochberg M, Lee DY, Gilpin AM, Fong HH, Langenberg P, Chen K, Li EK, Tam LS, Berman B.  Huo-Luo-Xiao-Ling (HLXL)-Dan, a Traditional Chinese Medicine, for Patients with Osteoarthritis of the Knee: A Multi-site, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial.  Osteoarthritis Cartilage. 2015 Jun 19. pii: S1063-4584(15)01215-7. doi: 10.1016/j.joca.2015.06.007. [Epub ahead of print]  PMID: 26099553.

  2. Moudgil KD, Berman BM.  Traditional Chinese medicine: potential for clinical treatment of rheumatoid arthritis.  Expert Rev Clin Immunol. 2014 May 12:1-4. [Epub ahead of print] .

  3. Manheimer E, Cheng K, Wieland LS, Min LS, Shen X, Berman BM, Lao L. Acupuncture for treatment of irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol. 2012; 107:835-847; doi: 10.1038/ajg.2012.66; published online 10 April 2012. PMID: 22488079. PMCID: PMC3671917.

  4. Manheimer E, Cheng K, Linde K, Lao L, Yoo J, Wieland S, van der Windt DAWM, Berman BM, Bouter LM. Acupuncture for peripheral joint osteoarthritis. Cochrane Database of Systematic Reviews. 2010, Issue 1. Art. No.: CD001977. DOI: 10.1002/14651858.CD001977.pub2. PMID: 20091527. PMCID: PMC3169099.

  5. Manheimer E, Cheng K, Linde K, Lao L, Yoo J, Wieland S, van der Windt DA, Berman BM, Bouter LM.  Acupuncture for peripheral joint osteoarthritis.  Cochrane Database Syst Rev. 2010 Jan 20;(1):CD001977.  PMID: 20091527. PMCID: PMC3169099.

  6. Zhang RX, Fan AY, Zhou AN, Moudgil KD, Ma ZZ, Lee DY, Fong HH, Berman BM, Lao L.  Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats.  J Ethnopharmacol. 2009 Jan 30;121(3):366-71. Epub 2008 Nov 28.  PMID: 19100323. PMCID: PMC2818782.

  7. Zhang GG, Singh B, Lee W, HandwergerB, Lao L,Berman B.Improvement of agreement in TCM diagnosis among TCM practitioners for persons with the conventional diagnosis of rheumatoid arthritis: effect of training. Journal of Alternative and Complementary Medicine. May 2008:14(4):381-386. PMID: 18576921.

  8. Chen K, Perlman A, Liao J, Lam A, Staller J, Sigal L.  Effects of external qigong therapy on osteoarthritis of the knee.  Clinical Rheumatology. 2008 Dec;27(12):1497-505. Epub 2008 Jul 25.  PMID: 18654733. PMCID: PMC2582590.

  9. Pradhan EK, Baumgarten M, Langenberg P, Handwerger B, Gilpin AK, Magyari T, Hochberg M, Berman B.  The Effect of Mindfulness-Based Stress Reduction in Rheumatoid Arthritis Patients.  Arthritis & Rheumatism. 2007, 57(7); 1134-1142.

  10. Manheimer E,Linde K, Lao L., Bouter LM, Berman B. Meta-analysis: acupuncture for osteoarthritis of the knee. Annals of Internal Medicine 2007 Jun;146 (12) 868-877.

  11. Zhang G, Lee WL, Bausell B, Lao L, Handwerger B, and Berman B. Variability in the traditional Chinese medicine (TCM) diagnoses and herbal prescriptions provided by three TCM practitioners for 40 patients with rheumatoid arthritis. Journal of Alternative and Complementary Medicine. 2005; 11(3):415-21.

  12. Berman B, Lao L, Langenberg P, Lee WL, Gilpin A, Hochberg M. Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial. Annals of Internal Medicine. 2004; 141(12):901-910.

  13. Zhang GG, Bausell B, Lao L, Lee WL, Handwerger B, Berman B. The variability of TCM pattern diagnosis and herbal prescription on rheumatoid arthritis patients. Alternative Therapies in Health and Medicine. 2004; 10(1):58-63.

  14. Singh BB, Berman B, Hadhazy V, Bareta J, Lao L, Zarow FM, Hochberg MC. Clinical decisions in the use of  acupuncture as an adjunctive therapy for osteoarthritis of the knee. Alternative Therapies. 2001;7(4): 58-65.

  15. Ezzo J, Hadhazy V, Birch S, Lao L, Kaplan G, Hochberg M, Berman B. Acupuncture for Osteoarthritis  of the Knee: A systematic review. Arthritis Rheumatism. 2001;44(4):819-825.

Irritable Bowel Syndrome

  1. Manheimer E, Cheng K, Wieland LS, Min LS, Shen X, Berman BM, Lao L. Acupuncture for treatment of irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol 2012; 107:835-847; doi: 10.1038/ajg.2012.66; published online 10 April 2012. PMID: 22488079. PMCID: PMC3671917.

  2. Manheimer E, Wieland LS, Cheng K, Min Li SM, Shen X, Berman BM, Lao L.  Acupuncture for Irritable Bowel Syndrome:  Systematic Review and Meta-Analysis.  The American Journal of Gastroenterology.  10 April 2012 [Epub ahead of print].  doi: 10.1038/ajg.2012.66. PMID: 22592702. PMCID: PMC3718572.

  3. Ren TH, Wu J, Yew D, Ziea E, Lao L, Leung WK, Berman B, Hu PJ, Sung JJ. Effects of neonatal maternal separation on neurochemical and sensory response to colonic distension in a rat model of irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G849-56.

  4. Lim, B., Manheimer, E., Lao, L., Ziea, E., Wisniewski, J., Liu, J., Berman, B. Acupuncture for treatment of irritable bowel syndrome. Cochrane Database of Systematic Reviews, 4, 2006.



  1. Ezzo J, Manheimer E, McNeely MI, Howell DM, Weiss R, Johansson KI, Bao T, Bily I, Tuppo CM, Williams AF, Karadibak D.  Manual lymphatic drainage for lymphedema following breast cancer treatment (Review).  Cochrane Database Syst Rev. 2015 May 21;5:CD003475. doi: 10.1002/14651858.CD003475.pub2.  PMID: 25994425.

  2. Pearce MJ, Coan A, Herndon JE, Koenig HG, & Abernethy A. Unmet spiritual care needs impact emotional and spiritual well-being in advanced cancer patients. Supportive Care in Cancer. 2012. Online first 10.1007/s00520-011-1335-1. PMID: 22124529.

  3. Bao T, Ye X, Skinner J, Cao B, Fisher J, Nesbit S, Grossman SA.  The analgesic effect of magnetic acupressure in cancer patients undergoing bone marrow aspiration and biopsy: a randomized, blinded, controlled trial.  J Pain Symptom Manage.  2011 Jun; 41(6):  995-1002.  Epub 2011 Feb 9.  PMID:  21306863.

  4. Zhang R, Liu B, Li A, Wang L, Ren K, Qiao JT, Berman BM, Lao L. Interleukin 1β facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit Phosphorylation. Neuroscience. 2008 Jul 17;154(4):1533-8. Epub 2008 May 7.  PMID: 18554806. PMCID: PMC2495055.

  5. Zhang R, Li A, Liu B, Wang L, Xin J, Ren K, Qiao JT, Berman BM, Lao L. Electroacupuncture attenuates bone cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model.  Eur J Pain. 2008 Oct;12(7):870-8. Epub 2008 Jan 24. PMID: 18221900. PMCID: PMC3107701.

  6. Lee MS, Chen K, Sancier K, Ernst E. Qigong for cancer treatment: a systematic review of controlled clinical trials.  ACTA Oncologica. 2007. 46(6):717-22.

  7. Zhang R-X, Li A, Liu B, Wang L, Ren K, Qiao J-T, Berman BM, Lao  L.  Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1β expression in a rat model. Anesthesia & Analgesia. 2007 Nov;105(5):1482-8.

  8. Zhang R-X, Liu B, Wang L, Ren K, Qiao J-T, Berman B, Lao L Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia. Pain. 2005; 118(1-2):125-136.

  9. Ezzo, JM, Vickers, AJ, Richardson, MA, Allen, C, Dibble, SL, Issell, BF, Lao, L., Pearl, M, Ramirez, G, Roscoe, JA, Shen, J, Shivnan, JC, Streitberger, K, Treish, I, Zhang, G. Acupuncture-Point Stimulation for Chemotherapy-Induced Nausea and Vomiting. Journal of Clinical Oncology. 2005:23(28):7188-98.


Addiction/Substance Abuse

  1. Chen KW, Berger CC, Forde DP, D'Adamo C, Weintraub E, Gandhi D.  Benzodiazepine use and misuse among patients in a methadone program.  BMC Psychiatry. 2011 May 19;11:90. 

  2. Chen KW, Banducci AN, Guller L, Macatee RJ, Lavelle A, Daughters SB, Lejuez CW. An examination of psychiatric comorbidities as a function of gender and substance type within an inpatient substance use treatment program. Drug Alcohol Depend. 2011 Apr 21. [Epub ahead of print].

  3. Chen KW, Comeford A, Shinnick P, Ziedonis DM.  Introducing Qigong meditation into residential addiction treatment:  a pilot study where gender makes a difference.  J Altern Complement Med. 2010 Aug 17, 16(8):875-882. 

  4. Kim SS, Ziedonis D, Chen K. Tobacco use and dependence in Asian Americans: A review of the literature. Nicotine & Tobacco Research. 2007; 9(2): 169-184.

  5. Steinberg, ML., Krejci, JA., Collett, K., Brandon, TH., Ziedonis, DM., Chen, K.  Relationship between self-reported task persistence and history of quitting smoking, plans for quitting smoking, and current smoking status in adolescents. Addictive Behaviors. 2007; 32 (7): 1451-1460.  PMCID: PMC2398683.

  6. Kim SS, Ziedonis D, Chen K: Tobacco use and dependence in Asian American and Pacific Islander adolescents: a review of the literature. J Ethn Subst Abuse. 2007; 6(3-4):113-142.

  7. Vega WA, Chen KW, William J. Smoking, drugs, and other behavioral health problems among multiethnic adolescents in the NHSDA.  Addictive Behaviors. 2007; 32(9):1949-56.

  8. Chen K, Killeya-Jones LA.  Understanding differences in marijuana use among urban black and suburban white high school students from two U.S. community samples. Journal of Ethnicity in Substance Abuse. 2006: 5(2): 51-73.

  9. Manheimer E, Anderson BJ, Stein MD. Use and assessment of complementary and alternative therapies by intravenous drug users. American Journal of Drug and Alcohol Abuse. 2003; 29(2):401-413.


In Vitro Fertilization

  1. Manheimer E, Stafford K, Liu J, Tierney J, Lao L, Berman B, Bouter L.  Effects of adjuvant acupuncture on pregnancy rates among women undergoing in vitro fertilization:  systematic review and meta-analysis.  CRD Register 2011:  CRD42011001309.

  2. Manheimer E., Zhang G., Udoff F., Haramati A., Langenberg P.,  Berman B., Bouter LM. The effects of acupuncture on pregnancy and live birth rates among women undergoing in vitro fertilization: a systematic review and meta-analysis. British Medical Journal (BMJ), 2008 Mar 8;336(7643):545-9.  PMID: 18258932. PMCID: PMC2265327.


Miscellaneous Topics

  1. D'Adamo CR, McMillin CR, Chen KW, Lucas EK, Berman BM.  Supervised Resistance Exercise for Patients with Persistent Symptoms of Lyme Disease.  Med Sci Sports Exerc. 2015 Apr 18. [Epub ahead of print]  PMID: 25899100.

  2. Witt CM, Pérard M, Berman B, Berman S, Birdsall TC, Defren H, Kummel S, Deng, G, Dobos G, Drexler A, Holmberg C, Horneber M, Jutte R, Knutson L, Kummer C, Volpers S, Schweiger D.  Using the framework of corporate culture in “mergers” to support the development of a cultural basis for integrative medicine – guidance for building an integrative medicine department or service.  Patient Preference and Adherence.  2015:9, 113-120. 

  3. Meng XZ, Wu F, Wei PK,  Xiu LJ, Shi J, Pang B, Sun DZ, Qin ZF, Huang Y, Lao L. A Chinese Herbal Formula to Improve General Psychological Status in Post-Traumatic Stress Disorder: A randomized placebo-controlled trial on Sichuan earthquake survivors. eCAM. Volume 2012 (2012), Article ID 691258, 11 pages doi:10.1155/2012/691258. PMID: 22028733. PMCID: PMC3199055.

  4. Ulbricht C, D’Adamo C, Edman J, Ernst E.  Roundtable Discussion: An Integrative Approach to Healthy Body Weight. Alternative and Complementary Therapies. 2011;17(2): 76-83.

  5. Kimbrough E, Lao L, Berman B, Pelletier KR, Talamonti WJ.  An integrative medicine intervention in a ford motor company assembly plant.  J Occup Environ Med. 2010 Mar;52(3):256-7.  PMID: 20216367.

  6. Chiaramonte, D. A piece of my mind. Who’s afraid of the empowered patient? JAMA. 2008 Sep 24;300(12):1393-4.  PMID: 18812523.

  7. Kimbrough E, Magyari T, Langenberg P, Chesney M, Berman B.  Mindfulness intervention for child abuse survivors.  J Clin Psychol. 2010 Jan;66(1):17-33.  2009 Dec 8. [Epub ahead of print].  PMID: 19998425.

  8. Berman B. Complementary and alternative medicine: Is it just a case of more tools for the medical bag? Clinical Journal of Pain. 2004; 20(1):1-2.